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Src/Bcr Abl

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Src/Bcr Abl

Chemical Structure Cat. No. Product Name CAS No.
TL02-59 Chemical Structure
BCP38228 TL02-59 1315330-17-6
TL02-59 is a novel potent and selective inhibitor of the myeloid Src-family kinase Fgr, suppressing AML cell growth in vitro and in vivo.
DGY-06-116 Chemical Structure
BCP37659 DGY-06-116 2556836-50-9
DGY-06-116 is an irreversible covalent, selective Src inhibitor.
PD173955-Analog1 Chemical Structure
BCP36116 PD173955-Analog1 185039-99-0
PD 173955-Analog1 is a potent c-Src inhibitor known to have activity against a variety of cancers including colon, lung, head and neck carcinoma.
CH6953755 Chemical Structure
BCP35548 CH6953755 2055918-71-1
CH6953755 is a potent, orally active and selective YES1 kinase (a member of the SRC family) inhibitor with an IC50 of 1.8 nM. CH6953755 inhibits YES1 kinase, leading to antitumor activity against YES1 Gene -amplified cancers in vitro and in vivo.
GMB-475 Chemical Structure
BCP31499 GMB-475 GMB-475
GMB-475 is a degrader of BCR-ABL1 tyrosine kinase based on PROTAC, overcoming BCR-ABL1-dependent drug resistance.
TG 100572 Hydrochloride Chemical Structure
BCP21364 TG 100572 Hydrochloride 867331-64-4
TG 100572 Hydrochloride is a multi-targeted kinase inhibitor which inhibits receptor tyrosine kinases and Src kinases; has IC50s of 2, 7, 2, 16, 13, 5, 0.5, 6, 0.1, 0.4, 1, 0.2 nM for VEGFR1, VEGFR2, FGFR1, FGFR2, PDGFRβ, Fgr, Fyn, Hck, Lck, Lyn, Src, Yes, respectively.
PD 166285 dihydrochloride Chemical Structure
BCP22349 PD 166285 dihydrochloride 212391-63-4
PD-166285 is a potent and broadly active protein tyrosine kinase inhibitor.
pp60c-src Fragment 521-533 Chemical Structure
BCP27682 pp60c-src Fragment 521-533 149299-77-4
pp60 c-src (521-533) (phosphorylated) is a peptide corresponding to the pp60c-src carboxy terminal regulatory domain; phosphorylated at Tyr527. Binds to pp60c-src and pp60v-src at the SH2 domain, suppressing their tyrosine kinase activity and transforming potential.
A-770041 Chemical Structure
BCP30674 A-770041 869748-10-7
A-770041 is selective and orally active Src-family Lck inhibitor; A-770041 is a 147 nM inhibitor of Lck (1 mM ATP) and is 300-fold selective against Fyn, the other Src family kinase involved in T-cell signaling.
1 NM-PP1 Chemical Structure
BCP09491 1 NM-PP1 221244-14-0
1 NM-PP1 is a cell-permeable PP1 analog that acts as a potent and selective inhibitor of mutant kinases over their wild-type progenitors.
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